Calcipotriol

FAQs:

What is Calcipotriol?
Calcipotriol, also known as calcipotriene, is a synthetic vitamin D2 derivative used topically to treat plaque psoriasis- a condition in which red scaly patches called plaque develop on the skin. Psoriasis is caused by the faster multiplication of the outer layer of skin cells that leads to scaly patches on the skin. Calcipotriol acts by slowing the overproduction of skin cells. It is available as ointment, solution, and cream.

What are the uses of Calcipotriol?
– Calcipotriol is used in the treatment of mild to moderate plaque psoriasis in adults. The topical cream or ointment is used for the treatment of plaque psoriasis on the arms, legs, or the lower part of the back. A topical solution is used to treat psoriasis on the scalp.
– Calcipotriol may be used alone or in combination with other drugs such as betamethasone and fluorouracil for the treatment of psoriasis and actinic keratosis, respectively. However, consult your doctor before taking medication.

What are the side effects of Calcipotriol?
Common side effects
– Skin irritation
– Skin rash
– Itchy skin
– Temporary burning or stinging sensation
– Thinning of skin
– Skin discoloration
– Dry skin
Serious side effects
– Allergic reaction
– High calcium levels that cause bone pain, constipation, vomiting, and nausea
Most of the side effects associated with Calcipotriol are mild and self-limiting that do not require any medical attention. However, if any side effects start to bother you or get worse, you should inform your doctor and seek medical attention.

1. How does Calcipotriol work?
During psoriasis, the outer layer of the skin multiplies faster than normal. It causes scaly patches to build upon the surface of the skin. Calcipotriol, when applied topically, works by slowing down the rate of skin cell growth that eases the inflamed and scaly areas. Calcipotriol also helps remove scaly skin.

3. Is Calcipotriol a vitamin D?
Calcipotriol is a synthetic vitamin D derivative indicated for the treatment of plaque psoriasis. It is applied topically on the scalp and other affected areas. It should not be used on the face as it may lead to irritation. Excessive exposure to natural or synthetic sunlight should be avoided during treatment with Calcipotriol.

4. Is Calcipotriene an immunosuppressant?
Calcipotriol is a class of drugs that belong to synthetic vitamin D derivatives that work by slowing down the production of skin cells and help relieve psoriasis. It is prescribed alone or with corticosteroids to treat mild to moderately severe psoriasis. Steroids such as betamethasone show immunosuppressive and anti-inflammatory properties.

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Side Effects:

– Skin irritation
– Skin rash
– Itchy skin
– Temporary burning or stinging sensation
– Thinning of skin
– Skin discoloration
– Dry skin
– Allergic reaction
– High calcium levels that cause bone pain, constipation, vomiting, and nausea

References:

https://go.drugbank.com/drugs/DB02300; https://medlineplus.gov/druginfo/meds/a608018.html; https://pubchem.ncbi.nlm.nih.gov/compound/Calcipotriol#:~:text=Calcipotriol%20is%20a%20seco%2Dcholestane,plaque%20psoriasis%20in%20adult%20patients.; https://www.drugs.com/cons/calcipotriene-topical.html; https://www.goodrx.com/calcipotriene/what-is; https://www.medicines.org.uk/emc/product/6899/smpc#gref; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709030/; https://www.sciencedirect.com/topics/neuroscience/calcipotriol;

More about Calcipotriol:

Calcipotriol, also known as calcipotriene, is a synthetic vitamin D2 derivative used topically to treat plaque psoriasis- a condition in which red scaly patches called plaque develop on the skin. Psoriasis is caused by the faster multiplication of the outer layer of skin cells that leads to scaly patches on the skin. Calcipotriol acts by slowing the overproduction of skin cells. It is available as ointment, solution, and cream.

Most of the side effects associated with Calcipotriol are mild and self-limiting that do not require any medical attention. However, if any side effects start to bother you or get worse, you should inform your doctor and seek medical attention.

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